{"product_id":"duobalance","title":"DuoBalance™ Candidate Medical Device | BV \u0026 Thrush | Coming Soon","description":"\u003ch2\u003eComing soon. Now advancing into clinical trials.\u003c\/h2\u003e\n\u003cp\u003eDuoBalance™ is our patented, antibiotic-free and acid-free candidate medical device, designed to address bacterial vaginosis (BV) and vaginal thrush by supporting the vaginal microbiome rather than clearing it. \u003cstrong\u003eIt is not yet available to buy.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch2\u003eWhy we're developing it\u003c\/h2\u003e\n\u003cp\u003eBV and thrush are the most common causes of vaginal discomfort, and for many women they keep coming back. Recurrent thrush alone affects an estimated 138 million women worldwide every year.\u003csup\u003e1\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003eAntibiotics and antifungals act indiscriminately, reducing the protective bacteria that keep the vaginal environment in balance. Acid-based gels can irritate: laboratory research found many over-the-counter lactic acid gels damaged lab-grown vaginal tissue.\u003csup\u003e2\u003c\/sup\u003e We believe there is a better way.\u003c\/p\u003e\n\u003ch2\u003eHow it's designed\u003c\/h2\u003e\n\u003cp\u003eDuoBalance™ is a prebiotic hydrogel. Instead of killing bacteria or forcing pH down with acid, it is designed to deliver glycogen, the preferred fuel of protective Lactobacillus species, so a woman's own microbiome can restore its balance.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eAntibiotic-free, antifungal-free and acid-free\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMucoadhesive\u003c\/strong\u003e, designed to stay in place where it's needed\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOne gel\u003c\/strong\u003e, designed to address both BV and thrush\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eThe research behind it\u003c\/h2\u003e\n\u003cp\u003eDuoBalance™ is built on laboratory research led by Prof Paul Long at King's College London, published in \u003cem\u003eJAC-Antimicrobial Resistance\u003c\/em\u003e in 2025.\u003csup\u003e3\u003c\/sup\u003e In tests on swabs from women with diagnosed BV and thrush, the hydrogel:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003esupported regrowth of lactobacilli to levels expected in a healthy vagina\u003c\/li\u003e\n\u003cli\u003eshifted the balance towards species found in women less likely to have repeat infections\u003c\/li\u003e\n\u003cli\u003esupported significantly more lactobacilli than a market-leading acid gel, in BV samples\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eThese are laboratory results. Clinical trials are designed to show how DuoBalance™ performs in women.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eWhat happens next\u003c\/h2\u003e\n\u003cp\u003eDuoBalance™ is now advancing into clinical trials, the essential step before any medical device can be made available. We're committed to doing this properly, because in women's health, evidence is the price of entry.\u003c\/p\u003e\n\u003cp\u003eIn the meantime, \u003ca href=\"\/products\/bloomcalma-ph-balanced-intimate-moisturising-gel-pregnancy-postpartum-30ml\"\u003eBloomCalma™\u003c\/a\u003e, our pH-balanced intimate moisturising gel for pregnancy and postpartum, is developed from the research behind our patented DuoBalance technology.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eCan I buy DuoBalance?\u003c\/strong\u003e\u003cbr\u003eNot yet. DuoBalance™ is a candidate medical device now advancing into clinical trials. It can only be made available once trials are complete and it has the required regulatory approval. Sign up for research updates to hear about its progress.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhen will DuoBalance be available?\u003c\/strong\u003e\u003cbr\u003eWe can't give a date yet. Clinical trials and regulatory review take time, and we won't rush the evidence. We'll share progress as the trials advance, so the best way to stay informed is to sign up for research updates.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow is DuoBalance different from BloomCalma?\u003c\/strong\u003e\u003cbr\u003eThey serve different needs. BloomCalma™ is a cosmetic, pH-balanced intimate moisturising gel for external use in pregnancy and postpartum, available now. DuoBalance™ is a candidate medical device designed to address BV and thrush, still in clinical development.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDoes DuoBalance contain antibiotics?\u003c\/strong\u003e\u003cbr\u003eNo. DuoBalance™ is designed to be antibiotic-free, antifungal-free and acid-free. Instead, it is designed to deliver glycogen, which supports the protective Lactobacillus bacteria already present in the vagina.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhat should I do if I have BV or thrush now?\u003c\/strong\u003e\u003cbr\u003eSpeak to a GP, pharmacist or sexual health clinic, especially if it's your first time, you're pregnant, or symptoms keep coming back. DuoBalance™ is not yet available, so follow the treatment advice you're given.\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eDenning DW, Kneale M, Sobel JD, Rautemaa-Richardson R. Global burden of recurrent vulvovaginal candidiasis: a systematic review. \u003cem\u003eThe Lancet Infectious Diseases\u003c\/em\u003e. 2018;18(11):e339-e347. \u003ca href=\"https:\/\/doi.org\/10.1016\/S1473-3099(18)30103-8\" target=\"_blank\" rel=\"noopener\"\u003edoi.org\/10.1016\/S1473-3099(18)30103-8\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eTyssen D, Hearps AC, Guntur K, et al. The impact of over-the-counter lactic acid containing vaginal gels on the integrity and inflammatory state of the vaginal epithelium in vitro. \u003cem\u003eFrontiers in Reproductive Health\u003c\/em\u003e. 2022;4:915948. \u003ca href=\"https:\/\/doi.org\/10.3389\/frph.2022.915948\" target=\"_blank\" rel=\"noopener\"\u003edoi.org\/10.3389\/frph.2022.915948\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eLong PF. A new paradigm for treating refractory and recurrent infectious vaginal discharge. \u003cem\u003eJAC-Antimicrobial Resistance\u003c\/em\u003e. 2025 Jul;7(Suppl 3):dlaf118.017. \u003ca href=\"https:\/\/doi.org\/10.1093\/jacamr\/dlaf118.017\" target=\"_blank\" rel=\"noopener\"\u003edoi.org\/10.1093\/jacamr\/dlaf118.017\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cem\u003ePowered by BiotaLife® Science\u003c\/em\u003e\u003c\/p\u003e","brand":"BiotaLife","offers":[{"title":"Default Title","offer_id":54504573305160,"sku":null,"price":24.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0962\/8637\/6264\/files\/BiotaLifeDuoBalanceinWarmSunlight.png?v=1793816175","url":"https:\/\/biotalife.com\/products\/duobalance","provider":"BiotaLife","version":"1.0","type":"link"}